Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 1.122


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TLX3chr5_+_1707362870.442.9e-02Click!
TLX1chr10_+_1028910600.154.7e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_79086087 6.772 NM_006820
IFI44L
interferon-induced protein 44-like
chr16_+_57406398 4.931 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr15_+_89182038 4.137 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr6_-_31550065 4.028 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr1_-_173020011 3.546 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr17_+_77030471 3.125 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr6_+_14117857 3.008 NM_001040280
NM_004233
CD83

CD83 molecule

chr2_-_7005764 2.810 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr8_-_80679897 2.793 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr6_+_14117486 2.746 NM_001251901
CD83
CD83 molecule
chr1_-_173174611 2.153 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr19_+_10397642 2.077 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr1_+_79115476 2.074 NM_006417
IFI44
interferon-induced protein 44
chr15_-_72523557 1.940 PKM2
pyruvate kinase, muscle
chr17_+_40439564 1.934 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr15_-_72523542 1.932 PKM2
pyruvate kinase, muscle
chr15_-_72523483 1.913 PKM2
pyruvate kinase, muscle
chr15_-_72523713 1.889 NM_001206796
NM_001206797
NM_001206798
NM_002654
NM_182470
NM_182471
PKM2





pyruvate kinase, muscle





chr12_+_124773709 1.885 NM_181709
FAM101A
family with sequence similarity 101, member A
chr6_-_43595046 1.858 GTPBP2
GTP binding protein 2
chr7_+_143078608 1.811 ZYX
zyxin
chr7_+_143079354 1.733 ZYX
zyxin
chr16_+_57662301 1.618 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr19_+_49376488 1.562 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chrX_-_13956530 1.540 GPM6B
glycoprotein M6B
chr15_-_40213087 1.498 NM_007223
GPR176
G protein-coupled receptor 176
chr1_+_101185195 1.489 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr1_-_32264215 1.386 SPOCD1
SPOC domain containing 1
chr1_+_113217278 1.301 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr11_-_128457452 1.300 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr1_+_113217574 1.283 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr19_-_47217576 1.279 NM_001079882
PRKD2
protein kinase D2
chr1_+_113217491 1.257 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr2_+_7017795 1.245 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr1_+_113217466 1.241 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr2_-_37899227 1.158 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr1_+_113217039 1.157 NM_001130079
NM_020963
MOV10

Mov10, Moloney leukemia virus 10, homolog (mouse)

chr1_+_155023781 1.137 ADAM15
ADAM metallopeptidase domain 15
chr9_-_117554809 1.113 NM_001204344
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr11_+_63974190 1.105 FERMT3
fermitin family member 3
chr9_+_35673852 1.103 NM_001216
CA9
carbonic anhydrase IX
chr1_-_157811491 1.080 NM_005894
CD5L
CD5 molecule-like
chr17_-_74483806 1.024 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr19_+_46806855 1.019 NM_152794
HIF3A
hypoxia inducible factor 3, alpha subunit
chr15_-_72501017 1.016 PKM2
pyruvate kinase, muscle
chr19_-_50400131 0.988 NM_152899
IL4I1
interleukin 4 induced 1
chr17_-_48474864 0.988 LRRC59
leucine rich repeat containing 59
chr7_+_22767101 0.963 IL6
interleukin 6 (interferon, beta 2)
chr2_-_11810254 0.963 NM_012344
NTSR2
neurotensin receptor 2
chr17_-_27948345 0.954 NM_032854
CORO6
coronin 6
chrX_+_46937889 0.949 RGN
regucalcin (senescence marker protein-30)
chr2_+_185463235 0.946 ZNF804A
zinc finger protein 804A
chr11_-_9225780 0.934 DENND5A
DENN/MADD domain containing 5A
chr11_+_61957687 0.931 NM_006552
SCGB1D1
secretoglobin, family 1D, member 1
chr11_+_5410606 0.920 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr6_-_43595079 0.916 GTPBP2
GTP binding protein 2
chr1_-_220101925 0.910 NM_018713
SLC30A10
solute carrier family 30, member 10
chr1_-_32264271 0.894 SPOCD1
SPOC domain containing 1
chrX_+_46937807 0.888 RGN
regucalcin (senescence marker protein-30)
chr2_-_37898768 0.886 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chrX_+_46937744 0.883 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr11_-_64764388 0.827 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr3_+_126261178 0.810 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr1_-_32281577 0.808 NM_144569
SPOCD1
SPOC domain containing 1
chr11_-_57089670 0.804 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr3_-_58563070 0.789 FAM107A
family with sequence similarity 107, member A
chrX_-_118284541 0.781 NM_020721
KIAA1210
KIAA1210
chr12_+_21168629 0.769 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr17_-_48474678 0.757 LRRC59
leucine rich repeat containing 59
chr2_+_185463092 0.751 NM_194250
ZNF804A
zinc finger protein 804A
chr6_+_150920998 0.748 NM_001029884
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr17_+_7211693 0.743 NM_001143762
EIF5A
eukaryotic translation initiation factor 5A
chr6_-_119470336 0.741 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr1_-_200992824 0.735 NM_001252100
NM_001252102
NM_001252103
NM_017596
KIF21B



kinesin family member 21B



chr18_-_74728677 0.704 MBP
myelin basic protein
chr3_+_48264836 0.699 NM_004345
CAMP
cathelicidin antimicrobial peptide
chrX_-_154688260 0.692 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr22_-_30960875 0.684 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr7_+_116165089 0.681 CAV1
caveolin 1, caveolae protein, 22kDa
chr1_-_47080793 0.681 NM_145279
MOB3C
MOB kinase activator 3C
chr12_-_53207843 0.672 NM_002272
KRT4
keratin 4
chrX_+_154114609 0.671 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr2_+_228336809 0.669 AGFG1
ArfGAP with FG repeats 1
chr9_-_124262035 0.666 GGTA1P
glycoprotein, alpha-galactosyltransferase 1 pseudogene
chr6_+_34204647 0.663 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr19_+_44084758 0.658 LOC390940
uncharacterized protein ENSP00000244321
chr12_+_111471827 0.641 NM_015267
CUX2
cut-like homeobox 2
chr12_+_57522247 0.633 NM_002332
LRP1
low density lipoprotein receptor-related protein 1
chr11_-_85397215 0.627 NM_152723
CCDC89
coiled-coil domain containing 89
chrX_-_110654373 0.627 NM_000555
DCX
doublecortin
chr13_+_113622758 0.626 MCF2L
MCF.2 cell line derived transforming sequence-like
chr3_-_155572166 0.626 NM_001190992
NM_004733
SLC33A1

solute carrier family 33 (acetyl-CoA transporter), member 1

chr7_+_22766765 0.625 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr1_-_27816676 0.625 NM_001201404
NM_006990
WASF2

WAS protein family, member 2

chr5_-_59783885 0.625 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_+_7210929 0.622 EIF5A
eukaryotic translation initiation factor 5A
chr12_+_100867739 0.612 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr10_-_128077072 0.611 NM_003474
NM_021641
ADAM12

ADAM metallopeptidase domain 12

chr22_-_46449972 0.608 NM_018280
C22orf26
chromosome 22 open reading frame 26
chr1_+_220701523 0.602 MARK1
MAP/microtubule affinity-regulating kinase 1
chr19_-_41388656 0.598 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr19_+_15783827 0.593 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr9_+_116918230 0.583 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr7_+_150065330 0.581 REPIN1
replication initiator 1
chr15_-_68724434 0.581 NM_001004439
ITGA11
integrin, alpha 11
chr22_-_39640956 0.579 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide
chr17_-_41910439 0.579 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr6_-_3227776 0.576 NM_178012
TUBB2B
tubulin, beta 2B class IIb
chrX_+_153770458 0.574 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr2_+_234296799 0.572 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr8_-_145701717 0.570 NM_003923
FOXH1
forkhead box H1
chr9_-_23821842 0.570 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_-_48014960 0.567 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr12_+_100867550 0.558 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr1_+_179262960 0.556 SOAT1
sterol O-acyltransferase 1
chr21_-_28217692 0.550 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_+_57522429 0.549 LRP1
low density lipoprotein receptor-related protein 1
chr2_+_112812799 0.542 NM_032824
TMEM87B
transmembrane protein 87B
chrX_+_154611748 0.541 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr10_-_128077062 0.540 ADAM12
ADAM metallopeptidase domain 12
chr19_+_58111244 0.538 NM_020880
ZNF530
zinc finger protein 530
chr19_+_46801632 0.537 NM_022462
NM_152796
HIF3A

hypoxia inducible factor 3, alpha subunit

chr3_+_190231839 0.533 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr2_+_150186498 0.533 NM_001195685
LYPD6
LY6/PLAUR domain containing 6
chr22_-_30867944 0.532 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr2_-_74734785 0.529 NM_032673
PCGF1
polycomb group ring finger 1
chrX_-_8700132 0.524 KAL1
Kallmann syndrome 1 sequence
chr10_+_88718287 0.523 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr14_-_76448091 0.518 NM_003239
TGFB3
transforming growth factor, beta 3
chr11_-_111636995 0.515 PPP2R1B
protein phosphatase 2, regulatory subunit A, beta
chr9_-_112970412 0.510 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr6_+_123100860 0.510 FABP7
fatty acid binding protein 7, brain
chr16_+_57653649 0.508 GPR56
G protein-coupled receptor 56
chr1_+_110453232 0.507 NM_000757
NM_172210
NM_172212
CSF1


colony stimulating factor 1 (macrophage)


chr3_-_14989616 0.503 LOC100505641
uncharacterized LOC100505641
chr19_-_6737603 0.495 NM_001080452
GPR108
G protein-coupled receptor 108
chr7_+_116165043 0.494 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr14_-_76447445 0.493 TGFB3
transforming growth factor, beta 3
chr2_-_74734498 0.492 PCGF1
polycomb group ring finger 1
chr19_+_52693054 0.491 NM_014225
PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha
chr20_+_9049660 0.491 NM_001172646
PLCB4
phospholipase C, beta 4
chr13_+_50069745 0.486 NM_001040443
PHF11
PHD finger protein 11
chr19_+_55344130 0.486 NM_012314
KIR2DS4
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
chr11_+_63974144 0.486 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr12_+_66218141 0.484 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr3_-_11610264 0.483 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr3_-_107809754 0.482 NM_001777
NM_198793
CD47

CD47 molecule

chr21_-_28217272 0.481 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr3_-_12200339 0.480 TIMP4
TIMP metallopeptidase inhibitor 4
chr19_-_49258646 0.480 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr11_-_35441501 0.478 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr14_+_73704204 0.473 NM_173462
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr1_-_27816542 0.471 WASF2
WAS protein family, member 2
chr7_+_73624328 0.470 LAT2
linker for activation of T cells family, member 2
chr1_-_243418675 0.469 NM_001042404
NM_001042405
NM_014812
CEP170


centrosomal protein 170kDa


chr12_-_109025825 0.468 NM_001206609
SELPLG
selectin P ligand
chr16_+_20420854 0.468 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr1_-_153538305 0.467 NM_005978
S100A2
S100 calcium binding protein A2
chr19_-_2456954 0.464 NM_032737
LMNB2
lamin B2
chr5_-_148758787 0.459 NM_014443
IL17B
interleukin 17B
chr19_-_6737589 0.456 GPR108
G protein-coupled receptor 108
chr5_-_16936290 0.455 MYO10
myosin X
chr2_+_150187028 0.454 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr1_+_31886659 0.454 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr7_+_73624347 0.449 LAT2
linker for activation of T cells family, member 2
chr16_+_56899118 0.447 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr9_+_136399877 0.443 NM_014694
ADAMTSL2
ADAMTS-like 2
chr11_-_30607762 0.443 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr6_-_68598987 0.441 ERVH-3
endogenous retrovirus group H, member 3
chr6_-_28891409 0.440 TRIM27
tripartite motif containing 27
chr11_+_74862031 0.440 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr21_+_43639930 0.434 NM_207174
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr7_+_86273867 0.434 GRM3
glutamate receptor, metabotropic 3
chr6_+_31583766 0.434 NM_032955
AIF1
allograft inflammatory factor 1
chr17_+_32646058 0.433 NM_005623
CCL8
chemokine (C-C motif) ligand 8
chr16_-_87903028 0.430 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr7_-_5463176 0.430 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr11_-_35441099 0.430 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr19_+_3708358 0.429 TJP3
tight junction protein 3 (zona occludens 3)
chr1_+_179262848 0.427 NM_001252511
NM_001252512
NM_003101
SOAT1


sterol O-acyltransferase 1


chr7_+_100770378 0.427 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr11_+_61717355 0.422 NM_001139443
NM_004183
BEST1

bestrophin 1

chr15_+_90118740 0.421 NM_152259
C15orf42
chromosome 15 open reading frame 42
chr7_+_116164838 0.420 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr15_+_45927217 0.419 NM_021199
SQRDL
sulfide quinone reductase-like (yeast)
chr5_-_176831183 0.416 F12
coagulation factor XII (Hageman factor)
chr8_+_104310660 0.416 NM_001164615
FZD6
frizzled family receptor 6
chr4_+_183245136 0.415 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr16_+_29674564 0.414 SPN
sialophorin
chr16_+_2867163 0.412 NM_006799
NM_144956
NM_144957
PRSS21


protease, serine, 21 (testisin)


chr12_+_57881735 0.411 NM_004990
MARS
methionyl-tRNA synthetase
chr6_+_34204663 0.406 HMGA1
high mobility group AT-hook 1
chr1_+_212782103 0.406 ATF3
activating transcription factor 3
chr8_+_22022677 0.405 BMP1
bone morphogenetic protein 1
chr4_+_81187741 0.403 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr1_-_1051458 0.402 C1orf159
chromosome 1 open reading frame 159
chr17_+_7210841 0.402 NM_001970
EIF5A
eukaryotic translation initiation factor 5A
chr1_+_165797060 0.401 UCK2
uridine-cytidine kinase 2
chr3_-_14989857 0.396 LOC100505641
uncharacterized LOC100505641
chr20_-_30060815 0.394 NM_001037500
DEFB124
defensin, beta 124

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 1.12e-04 GO:0044459 plasma membrane part
1.62 1.34e-04 GO:0031226 intrinsic to plasma membrane
1.62 1.77e-04 GO:0005887 integral to plasma membrane
1.66 4.78e-04 GO:0044421 extracellular region part
1.39 5.47e-03 GO:0005576 extracellular region
2.00 3.05e-02 GO:0005578 proteinaceous extracellular matrix
1.50 3.46e-02 GO:0000267 cell fraction
1.58 3.82e-02 GO:0005626 insoluble fraction
1.90 3.82e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.55 2.29e-02 GO:0005102 receptor binding